Modern diet and lifestyle affect our health
In the last 6-8 generations, but particularly in the last 2-3, modern diet and lifestyle changes have prompted a dramatic increase in “civilisation diseases” like obesity, diabetes and cardiovascular disease.1 The number of people living with diabetes has quadrupled from 1980 to 2014, whilst cardiovascular disease is the leading cause of death worldwide.2,3 At the same time, these changes to diet and lifestyle have impacted our gut health which in turn effects our overall health.4
What is ‘good gut health’?
You will often hear the term ‘microbiome’ when referring to gut health. The microbiome consists of both helpful and harmful bacteria. A healthy gut microbiome is one that is rich and diverse. When your gut microbiota is out of balance, this can be associated with poor health and disease.4
It is evident that maintaining good gut health is good for us. But what does the research say about how this works?
70-80% of immune cells are present in the gut
With 70-80% of immune cells being present in the gut, the gut microbiome has a profound influence on our immune system.5 It helps to support our immune response and defend against unwanted germs. Imbalances in the gut microbiome have been associated with immune-related disorders such as allergies and asthma6 as well as autoimmune diseases, including type 1 diabetes.7
Gut-brain axis
The gut microbiome has also been linked to brain function and mental health via the gut-brain axis.8 This is a two-way communication pathway between the gut and the brain which involves the gut microbiome, nerves and hormones. Imbalances in our gut microbiome have been associated with poor brain function and stress as well as disorders such as depression.8,9 It is clear that good gut health could help support our mental health.
Formulated with the modern world in mind
At ADDAY, we understand that life gets busy. We’d like to simplify it for you. With this in mind, combining care and scientific findings, our goal was to create products that help you meet your health goals whilst also supporting good gut health. The little things add up, and by carefully combining multiple science-driven ingredients, we’ve created high-quality products that allow you to supplement your diet your way.
Pro Immunity: For support of immune and digestive function
Live bacteria, fermentable fibres and micronutrients may support gut health and immune system function. 10,11
Our Pro Immunity product contains live bacteria, fermentable fibres, botanicals and micronutrients, and is formulated to support your immune and digestive function. Botanical ingredients including green-tea extract, curcumin, blueberry extract and elderberry extract provide an antioxidant boost, whilst green tea extract and curcumin have been shown to reduce inflammation. 12-14
Pre Immunity: Fermentable fibres that feed your gut good bacteria
Both soluble and insoluble fibres play an important role in supporting gut health.15 Pre Immunity is a complex source of soluble and insoluble fibre, selected specifically to compliment good bacteria. Pre Immunity contains fibre, vitamins, mineral and botanicals that together support the diversity of the microbiome.
Weight Balance: Support your digestion, microbiome and metabolism
Evidence has shown that an imbalance of gut bacteria could promote fat storage, increase appetite and inflammation.16 Weight Balance is a mixture of 8 gut-friendly bacteria plus fermentable fibres in the form of sugar beet fibre and konjac glucomannan. Other ingredients include choline bitartrate, green tea extract and chromium picolinate. These ingredients support a healthy gut microbiome which in turn may help to promote a healthy weight in multiple ways, such as influencing appetite, mood and regulating hormones.17-19
Mind focus: Gut friendly bacteria, botanicals and micronutrients for cognitive support
We know that brain and gut communicate through the gut-brain axis.8 Mind Focus is a unique combination of 9 strains of gut-friendly bacteria in addition to ashwagandha, lion's mane extract, lemon balm extract, L-theanine, L-tyrosine, blueberry extract and citicoline. It also contains 11 micronutrients including iron, vitamin B6 and B12 that contribute to normal cognitive function, normal psychological function and the reduction of tiredness and fatigue.19-24
Symbiotic: The power of gut-friendly bacteria plus fermentable fibres
A symbiotic is a mixture of gut-friendly bacteria and fermentable fibres that work together in your gut. They work by the fermentable fibres providing food for the gut- friendly bacteria, allowing them to benefit your gut health.25
Symbiotic combines 8 strains of good bacteria including bifidobacterium and lactobacillus. These gut-friendly bacteria are delivered alongside sugar beet fibre, a fermentable fibre. Together these ingredients support the growth and diversity of the gut microbiome. 26
Take care of your gut microbiome
Research into the area of gut microbiome and health is growing and we are beginning to understand more about these relationships over time. Maintaining a diverse and balanced gut microbiome through a healthy diet, regular exercise and avoiding unnecessary antibiotic use is considered beneficial for overall health and well-being.
References
- Kopp W. How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases. Diabetes Metab Syndr Obes. 2019;12:2221-2236. Published 2019 Oct 24. doi:10.2147/DMSO.S216791 2. Moles L, Otaegui D. The Impact of Diet on Microbiota Evolution and Human Health. Is Diet an Adequate Tool for Microbiota Modulation?. Nutrients. 2020;12(6):1654. Published 2020 Jun 2. doi:10.3390/nu12061654 2. https://www.who.int/news-room/fact-sheets/detail/diabetes 3. https://www.acc.org/About-ACC/Press-Releases/2023/12/11/18/48/New-Study-Reveals-Latest-Data-on-Global-Burden-of-Cardiovascular-Disease#:~:text=Global%20death%20counts%20due%20to,at%20553%20deaths%20per%20100%2C000. 4. Rinninella E, Raoul P, Cintoni M, et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms. 2019;7(1):14. Published 2019 Jan 10. doi:10.3390/microorganisms7010014 5. Wiertsema SP, van Bergenhenegouwen J, Garssen J, Knippels LMJ. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. 2021;13(3):886. Published 2021 Mar 9. doi:10.3390/nu13030886 6. Zimmermann P, Messina N, Mohn WW, Finlay BB, Curtis N. Association between the intestinal microbiota and allergic sensitization, eczema, and asthma: A systematic review. J Allergy Clin Immunol. 2019;143(2):467-485. doi:10.1016/j.jaci.2018.09.025 7. Jamshidi P, Hasanzadeh S, Tahvildari A, et al. Is there any association between gut microbiota and type 1 diabetes? A systematic review. Gut Pathog. 2019;11:49. Published 2019 Oct 14. doi:10.1186/s13099-019-0332-7 8. Cooke MB, Catchlove S, Tooley KL. Examining the Influence of the Human Gut Microbiota on Cognition and Stress: A Systematic Review of the Literature. Nutrients. 2022;14(21):4623. Published 2022 Nov 2. doi:10.3390/nu14214623 9. Alli SR, Gorbovskaya I, Liu JCW, Kolla NJ, Brown L, Müller DJ. The Gut Microbiome in Depression and Potential Benefit of Prebiotics, Probiotics and Synbiotics: A Systematic Review of Clinical Trials and Observational Studies. Int J Mol Sci. 2022;23(9):4494. Published 2022 Apr 19. doi:10.3390/ijms23094494 10. Maggini S, Pierre A, Calder PC. Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients. 2018;10(10):1531. Published 2018 Oct 17. doi:10.3390/nu10101531 11. Liu Y, Wang J, Wu C. Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics. Front Nutr. 2022;8:634897. Published 2022 Jan 3. doi:10.3389/fnut.2021.634897 12. Wang S, Li Z, Ma Y, et al. Immunomodulatory Effects of Green Tea Polyphenols. Molecules. 2021;26(12):3755. Published 2021 Jun 20. doi:10.3390/molecules26123755 13. Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65(11):1631-1652. doi:10.1007/s00018-008-7452-4 14. Młynarczyk K, Walkowiak-Tomczak D, Łysiak GP. Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry. J Funct Foods. 2018;40:377-390. doi:10.1016/j.jff.2017.11.025 15. https://www.healthline.com/health/soluble-vs-insolublefiber#:~:text=Benefits%20of%20each%20type%20of%20fiber&text=Soluble%20fiber%20may%20reduce%20blood,less%20strain%20on%20your%20bowel. 16. Liu BN, Liu XT, Liang ZH, Wang JH. Gut microbiota in obesity. World J Gastroenterol. 2021;27(25):3837-3850. doi:10.3748/wjg.v27.i25.3837 17. Noormohammadi M, Ghorbani Z, Löber U, et al. The effect of probiotic and synbiotic supplementation on appetite-regulating hormones and desire to eat: A systematic review and meta-analysis of clinical trials. Pharmacol Res. 2023;187:106614. doi:10.1016/j.phrs.2022.106614 18. Elsawy G, Abdelrahman O, Hamza A. Effect of choline supplementation on rapid weight loss and biochemical variables among female taekwondo and judo athletes. J Hum Kinet. 2014;40:77-82. Published 2014 Apr 9. doi:10.2478/hukin-2014-0009 19. https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2010.1798 20. https://www.efsa.europa.eu/en/efsajournal/pub/1225 21. https://www.efsa.europa.eu/en/efsajournal/pub/1756 22. Sanborn V, Azcarate-Peril MA, Updegraff J, Manderino L, Gunstad J. Randomized Clinical Trial Examining the Impact of Lactobacillus rhamnosus GG Probiotic Supplementation on Cognitive Functioning in Middle-aged and Older Adults. Neuropsychiatr Dis Treat. 2020;16:2765-2777. Published 2020 Nov 13. doi:10.2147/NDT.S270035 23. Kim CS, Cha L, Sim M, et al. Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. J Gerontol A Biol Sci Med Sci. 2021;76(1):32-40. doi:10.1093/gerona/glaa090 24. Pratte MA, Nanavati KB, Young V, Morley CP. An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). J Altern Complement Med. 2014;20(12):901-908. doi:10.1089/acm.2014.0177 25. https://www.webmd.com/digestive-disorders/synbiotics-what-to-know1 26. Gomez Quintero DF, Kok CR, Hutkins R. The Future of Synbiotics: Rational Formulation and Design. Front Microbiol. 2022;13:919725. Published 2022 Jul 22. doi:10.3389/fmicb.2022.919725